Relationship between membrane fatty acids and cognitive symptoms and information processing in individuals at ultra-high risk for psychosis

SW Kim; MR Schäfer; CM Klier; M Berk; S Rice; K Allott; CF Bartholomeusz; SL Whittle; E Pilioussis; C Pantelis; PD McGorry; GP Amminger

Journal article

Relationship between membrane fatty acids and cognitive symptoms and information processing in individuals at ultra-high risk for psychosis

SW Kim, MR Schäfer, CM Klier, M Berk, S Rice, K Allott, CF Bartholomeusz, SL Whittle, E Pilioussis, C Pantelis, PD McGorry, GP Amminger

Schizophrenia Research | Published : 2014

DOI: 10.1016/j.schres.2014.06.032

Abstract

Cognitive symptoms and impairment are central to schizophrenia and often an early sign of this condition. The present study investigated biological correlates of cognitive symptoms and performance in individuals at ultra-high risk (UHR) for psychosis. The study sample comprised 80 neuroleptic-naïve UHR individuals aged 13-25. years. Associations among erythrocyte membrane fatty acid levels, measured by gas chromatography, and cognitive functioning were investigated in UHR patients. Subjects were divided into terciles based on their scores on the cognitive factor of the Positive and Negative Syndrome Scale. The Zahlen-Verbindungs Test (ZVT) (the number-combination test) was also used as a mea..

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University of Melbourne Researchers

Michael Berk Author

Simon Rice Author

Kelly Allott Author

Cali Bartholomeusz Author

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Grants

Awarded by Stanley Medical Research Institute

Funding Acknowledgements

This study was supported by grant 03T-315 from the Stanley Medical Research Institute. G.P.A. was supported by grant 566529 from the National Health and Medical Research Council, Australia. C. P. was supported by a NHMRC Senior Principal Research Fellowship (ID: 628386) and NARSAD Distinguished Investigator Award (ID: 18722). The funding sources had no further role in the study design; in the analysis and interpretation of data; and in the writing of the manuscript.